A culturally mature picture of science and technology at once celebrates past contributions and calls for more humble perspective. Many future advances in science and technology will directly support Cultural Maturity. At the same time, many of the most important future science- and technology-related creative insights will surely have as much to do with what we should do as what we can do. Mature understanding also challenges science’s status as a bringer of last-word truth. While this does not make science any less significant, it does bring attention to the importance of viewing science’s contribution from a larger systemic vantage.